Studies on the Mechanism of Squalene Biosynthesis
نویسندگان
چکیده
منابع مشابه
Mechanism of squalene cyclization. The biosynthesis of fusidic acid.
It is generally accepted that the C-20 cation or its stabilized equivalent is an intermediate in the biosynthesis of certain triterpenes and sterols. To evaluate this hypothesis the biosynthesis of the protosterol fusidic acid was investigated. Fusidic acid was biosynthesized by incubating the fungus Fusidium coccineum on a medium containing (3RS,4R)(2-14C,4-3H)-meva10nic acid (MVA). The obtain...
متن کاملFurther observations on the biosynthesis of squalene.
We have previously reported that in the synthesis of squalene from 6 molecules of 5-Dt-mevalonic acid in crude yeast extracts, 10 out of a possible 12 atoms of deuterium are retained, and that the deficit of 2 atoms of deuterium is due to losses occurring when the central carbon-carbon bond of squalene is formed (1, 2). These conclusions were based on the following experimental findings: (a) sq...
متن کاملStudies on Squalene Epoxidase of Rat Liver*
Rat liver microsomes previously heated to 50” for 5 mm accumulate 2,3-oxidosqualene on incubation with squalene. Squalene epoxidase activity can be assayed either with squalene and heated microsomes or with lO,ll-dihydrosqualene and intact microsomes. In common with other monooxygenases, the epoxidase requires TPNH and molecular oxygen. Both a soluble fraction of rat liver and microsomes are ne...
متن کاملMechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate.
Several mechanisms that utilize farnesyl pyrophosphate and nerolidyl pyrophosphate as condensing substrates have been postulated for the asymmetric condensation reaction in squalene biosynthesis. Although there is ample evidence that farnesyl pyrophosphate is a substrate for this reaction, there has been no information concerning the role of nerolidyl pyrophosphate. We have made the following o...
متن کاملsurvey on the rule of the due & hindering relying on the sheikh ansaris ideas
قاعده مقتضی و مانع در متون فقهی کم و بیش مستند احکام قرار گرفته و مورد مناقشه فقهاء و اصولیین می باشد و مشهور معتقند مقتضی و مانع، قاعده نیست بلکه یکی از مسائل ذیل استصحاب است لذا نگارنده بر آن شد تا پیرامون این قاعده پژوهش جامعی انجام دهد. به عقیده ما مقتضی دارای حیثیت مستقلی است و هر گاه می گوییم مقتضی احراز شد یعنی با ماهیت مستقل خودش محرز گشته و قطعا اقتضاء خود را خواهد داشت مانند نکاح که ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62836-4